Using Mouse to control UI

I am looking to make a game that is played on one display, while also having a UI on a different display. The UI will have sliders that can adjust parameters within the game as it is being played. I was just wondering if it was possible to set up a controller that players can use to move the avatar on display 1 while also having the mouse set up to control the UI on the second display.

Not from one Unity program, I don’t think. You’d have to have two separate programs that use some form of local networking to communicate with each other.

The only way I can think of it working out of a single EXE is if you utilize EyeFinity or something, but I can’t (or simply don’t want to) even imagine the complexities of paring it back down to individual screens from there.