Please move the project folder somewhere readable and writable is the message I get each time I try to use Unity 5.6

When creating a New Project, Unity fails to start and a message comes back requesting Please move the project folder somewhere readable and writable

check windows defender virus and threat setting and uncheck controlled folder access.

More than likely, your project folder is in a READONLY section of your harddrive. You need to put it somewhere public, usually it is in Public Documents.

What worked for me is opening unity as administrator.
Source: Unity3diy

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@simpro try this

Make sure that you have enough space on your harddrive.
My harddrive had 0 Bytes free space, after deleting some files it worked again.